Utkan Demirci


Affiliation: Stanford University, CA, USA
E-mail address: utkan@stanford.edu

Utkan Demirci is an Associate Professor with tenure at the Stanford University School of Medicine, Palo Alto, CA. Before Stanford, he was an Associate Professor of Medicine and Health Sciences and Technology at the Harvard Medical School and Massachusetts Institute of Technology Health Sciences and Technology division. He received his bachelor’s degree (summa cum laude) from the University of Michigan, Ann Arbor, his master’s degrees in Electrical Engineering in 2001 and in Management Science and Engineering in 2005, and his doctorate in Electrical Engineering in 2005 all from Stanford University. Dr. Demirci received the IEEE EMBS Early Career Award; IEEE EMBS Translational Science Award; NSF CAREER Award; Coulter Foundation Early Career Award; HMS-Young Investigator Award; and Chinese National Science Foundation International Young Scientist Award. In 2006, he was selected to TR-35 as one of the world’s top 35 young innovators under the age of 35 by the MIT Technology Review. Dr. Demirci has published over 110 peer-reviewed journal publications, 14 book chapters, 4 edited books and holds more than 20 issued or pending U.S. and international patents. He is the Editor-in-Chief of the journal Advanced Health Care Technologies.

Abstract

Label-Free Magnetic Additive Biomanufacturing Technologies to Isolate and Sort Circulating Tumor Cells and Microemboli

Micro- and nano-scale technologies can have a significant impact on medicine and biology in the areas of cell manipulation, diagnostics and monitoring. At the convergence of these new technologies and biology, we research for enabling solutions to the real world problems at the clinic. Emerging nano-scale and microfluidic technologies integrated with biology offer innovative possibilities for creating intelligent, mobile medical lab-chip devices that could transform diagnostics and monitoring, tissue engineering and regenerative medicine. In this talk, we will present an overview of our laboratory's work in these areas focussed on applications in magnetic levitation methods for assembling cells and label free sorting of rare cells from whole blood. Cells consist of micro- and nano-scale components and materials that contribute to their fundamental magnetic and density signatures. Previous studies have claimed that magnetic levitation can only be used to measure density signatures of nonliving materials. Here, we demonstrate that both eukaryotic and prokaryotic cells can be levitated and that each cell has a unique levitation profile. Furthermore, our levitation platform uniquely enables ultrasensitive density measurements, imaging, and profiling of cells in real-time at single-cell resolution. This method has broad applications, such as the label-free identification and sorting of CTCs and CTM with broad applications in drug screening in personalized medicine.